It goes without saying that the universe of Resident Evil would be a horrifying place to exist. The world is constantly under threat of corrupt corporations, cultists, and terrorists unleashing viruses that turn innocent people into zombies and bio-engineered monstrosities that can rip you to shreds.
With the Resident Evil 4 Remake on the way, there is no doubt that there will be new living nightmares lying in wait to prey upon unsuspecting players. So, to help prepare ourselves for the future monstrosities we will have to face, let us look back on the main storyline of the Resident Evil series from Resident Evil 0 to the beginning of Resident Evil Village.
Be warned: this retrospective will contain massive spoilers for every game summarized on this list. Also, we will include the remakes of Resident Evil 1, 2, and 3 instead of the original PlayStation One versions as they are likely regarded as the canon versions now. While there may be some plot deviations between the remakes and original titles, the general narrative of each title remains the same.
Final warning: There are major spoilers ahead!
Resident Evil 0
Our tale begins in July 1998. We open to a scene of the Ecliptic Express, a train owned by the pharmaceutical company, the Umbrella Corporation, traveling through the Arklay Mountains.
However, its peaceful joyride is cut short as it is suddenly attacked by a swarm of gigantic leech monsters bursting through the windows and devouring the passengers. While this massacre is unfolding, a mysterious man singing a choir song is observing the carnage from afar.
Two hours later, we cut to a helicopter carrying an elite police force unit called the Special Tactics and Rescue Service (S.T.A.R.S. for short) to Arklay Mountains for their latest mission. Recently, a series of grisly, cannibalistic murders have been circulating within Raccoon City. The only clue Raccoon City’s police department has as to who’s been committing these crimes lies within the Arklay Mountains where the murders first began. So, they assigned their S.T.A.R.S. division to investigate the region and bring in the ones responsible for these heinous acts.
S.T.A.R.S. initially send in their Bravo Team on a helicopter to the Arklay Mountains to begin the search. On their way to the last murder sighting, the helicopter starts to unexpectedly malfunction and crash lands into Arklay Mountains’ forests. Bravo Team then begins searching the immediate area while their pilot, Kevin Dooley, stays behind to guard the remains of their chopper.
Bravo Team then comes across a wrecked military vehicle with its drivers dead and its only surviving occupant, a former marine who has been court-martialled and sentenced to death, Billy Coen, is nowhere to be seen. Thinking that Billy took advantage of the crash to murder his captors and escape, Bravo Team’s captain, Enrico Marini, orders the rest of his squad to split up and apprehend Billy.
During their search, Rebecca Chambers, Bravo Team’s field medic, discovers the ruined Ecliptic Express and moves in to investigate it. She then finds the train’s deceased occupants whose bodies are already beginning to rot…or so it seems. As Rebecca is taken aback by the scene, the passengers suddenly begin rising up one by one to attack her. Rebecca quickly guns them down but is still horrified by what she’s seen as she thought they were already dead.
Rebecca continues searching the train until she gets ambushed by Billy Coen, who holds her up at gunpoint but relents once he realizes that she isn’t a zombie. She attempts to arrest him, but Billy tells her to get lost and leaves.
Rebecca feels frustrated for being outplayed so easily by Billy, but she doesn’t have time to reflect as a body comes crashing through one of the windows. It turns out to be one of her Bravo teammates, Edward Dewey, and he is mortally wounded. Edward utters with his dying breath that Bravo Team has been attacked by zombies and monsters.
Rebecca then gets contacted on her radio by Enrico Marini, who informs her that he has uncovered documents containing background information on Billy from the wrecked wagon. According to files, Billy Coen received the death sentence for killing 23 people and was admitted to a mental hospital for violent behavior.
Rebecca continues her search of the train with the warning about Billy in mind, eventually coming across potentially another survivor. When she tries to communicate with the man, his body falls about and turns into the leeches which attacked the train. They attempt to overwhelm Rebecca, but Billy comes in to save her at the last minute, earning her trust.
Billy and Rebecca then spot the mysterious choir singer from the beginning of the game, surrounded by leeches, implying this character has control over them. The train suddenly begins to move again, so Rebecca and Billy decide to call a truce and work together to figure out what’s going on.
Unbeknownst to our protagonists, the Ecliptic Express is being operated by Umbrella’s security forces who are taking it to one of their facilities for inspection. All the while they’re being monitored by Umbrella scientists, Dr. William Birkin and Albert Wesker, the captain of the S.T.A.R.S. unit, which reveals to us that Bravo Team was being set up from the start, but for what end? As Wesker instructs the Umbrella soldiers over the radio, the leeches sneak up and attack the soldiers, destroying the train’s controls which leads to the locomotive speeding out of control.
Rebecca and Billy make it to the control room and try to slow the train. While they were successful in stopping the train from speeding into a wall, they were too late to prevent it from derailing, and it grinds to a halt. They exit the destroyed train and find themselves inside a mysterious underground train station beneath the Arklay Mountains, infested with more zombies and other mutated creatures.
After exiting the train station, Rebecca and Billy enter a building that appears to be a school built by Umbrella for training potential future employees. They then discover that this school is actually a front, it is in fact a research site for developing and testing biological weapons run by one of the co-founders of the Umbrella Corporation, Dr. James Marcus.
Albert Wesker and William Birkin discover Billy and Rebecca’s intrusion through hidden security cameras, but the video feed gets cut off by the mysterious choir singer. The singer proudly declares he was responsible for the attack on the Ecliptic Express and has spread something called the ‘T-Virus’ throughout their laboratories, all to exact revenge on Umbrella for murdering Dr. Marcus.
William Birkin and Albert Wesker theorize that this self-righteous interloper is in fact, Dr. Marcus, who has somehow been brought back from the dead and is using the leeches to wreak havoc on Umbrella. Fearing the damage caused by Dr. Marcus will cause Umbrella’s illicit activities to be leaked to the public and lead to its financial ruin, they begin planning their agendas should Umbrella fall.
Albert Wesker will continue his mission to gather 'combat data' by bringing the rest of the S.T.A.R.S. unit to the Spencer Mansion. While William Birkin plans to escape Umbrella and complete his ‘G-Virus’ research, but not before activating the school’s self-destruct sequence, hoping the explosion will take out the intruders and any incriminating evidence against them.
While that’s going on, Billy and Rebecca continue their trek through the Umbrella school. During their journey, Rebecca manages to get Billy to confess why he was sentenced to die since he acts nothing like the psychopath his official records make him out to be. The truth is that Billy was blamed for a military operation going south in Africa. While searching for a guerrilla force base, Billy’s unit suffered heavy casualties due to bad intel and Billy disobeyed orders to shoot innocent villagers. So, Billy was used as a scapegoat by the US government to cover up the incident.
After battling their way through more failed science experiments, puzzles, and death traps, they discover files that reveal the disturbing experiments that Dr. Marcus was conducting. He has used the school’s children as guinea pigs to test out viruses that the Umbrella Corporation was developing called the Progenitor Virus and the Tyrant Virus (a.k.a. T-Virus). He also created the mutant leeches and used them as carriers of the T-Virus to infect his child test subjects and many others. However, rifts began to form between Dr. Marcus and one of the founding members of Umbrella, Oswell E. Spencer, who is also its CEO. Dr. Marcus suspects that Spencer was planning to steal his research for himself.
Rebecca and Billy later get separated during an encounter with monkey-like monsters. Rebecca then discovers another Umbrella research lab beneath the school where man-made monsters called Bio-Organic Weapons (B.O.W. for short) were being developed. During her search for Billy, she runs into Enrico who managed to get in through another back entrance. He tells her this research facility leads to an old mansion owned by Umbrella where the rest of Bravo Team should be waiting for them. However, Rebecca elects to stay behind so she can rescue Billy as she has grown fond of him. Enrico reluctantly agrees to let her stay while he goes to meet with Bravo Team.
Rebecca eventually reunites with Billy, finding him inside a pool where Dr. Marcus discards his test subjects after they cease being useful. Soon afterward, they are confronted by the mysterious choir singer who reveals himself to be the 'Queen Leech', one of Dr. Marcus’ finest creations. It explains that ten years ago, Dr. Marcus was assassinated by Umbrella’s security, and his research on the Progenitor Virus and T-Virus was stolen by Albert Wesker and William Birkin on Spencer’s orders.
When Dr. Marcus’s body and his leeches were dumped in a river, the Queen Leech infected Dr. Marcus’ dead body and used it as a food source to survive. For the next ten years, the T-Virus within Queen Leech mutated and gave it the ability to transform into a younger version of Dr. Marcus, inheriting the doctor’s memories after eating his brain. Now believing itself to be Dr. Marcus reborn through divine intervention, the Queen Leech began a quest for vengeance to destroy Umbrella and the world.
The Queen Leech then transforms into its true mutant form and attacks Rebecca and Billy as it sees them as a threat to its plans. The battle was brutal and intense, but Rebecca and Billy manage to seemingly kill the Leech Queen after exhausting nearly all of their ammo. Shortly after, they discover an elevator shaft that will take them back to the school. The Queen Leech then revives itself using the T-Virus to heal its wounds and chases after Billy and Rebecca. To make matters worse, an alarm goes off saying that a self-destruct sequence had begun and that it will blow up the research facility and the school.
After being cornered in a helicopter cargo warehouse by the Queen Leech, Rebecca and Billy engage the disgusting monster in a desperate last stand. With little ammo left all hope seems lost, until one of the Queen Leech’s attacks breaks a hole in the ceiling letting in the sunlight which causes it to burn. Realizing that the Queen Leech is sensitive to light, Rebecca immediately runs to the warehouse controls which operate the retractable roof, and opens it up to bathe the Queen Leech in searing sunlight.
Billy then finishes off the Queen Leech blasting it with a magnum, sending it crashing back down the elevator shaft where it is utterly destroyed by the exploding facility. Rebecca and Billy manage to escape the inferno in the nick of time to emerge back into the Arklay Mountains. Rebecca then spots the old mansion Enrico mentioned earlier in the distance and decides to do one last favor for Billy before they part company. She takes his dog tags and declares him legally dead so he can start a new life as a free man without being executed for crimes he didn’t commit.
Billy agrees to this arrangement and thanks Rebecca with a salute before leaving her to rendezvous with Bravo Team. Rebecca then says a tearful goodbye and makes her way to the mansion, knowing full well that this hellish mission has only just begun.
Resident Evil 0
Discover the origins of the Mansion Incident with Resident Evil 0. Witness the events that would begin the horrifying saga of Resident Evil with Bravo Team's Rebecca Chambers as she struggles to survive against hordes of zombies and uncover dark secrets behind the creation of the T-Virus.
Buy from: Xbox
While Bravo Team crash was busy trying to survive in the Arklay Mountains, the rest of the S.T.A.R.S. unit back in Raccoon City desperately tried to contact them. After failing to contact their radios, their captain Albert Wesker, orders the S.T.A.R.S Alpha Team to assemble and get ready to deploy to Arklay Mountains and rescue Bravo Team. Little does Alpha Team know that Albert Wesker is one of the masterminds behind this disaster and is secretly leading them to their doom.
Once Alpha Team arrives, they find the Bravo Team's crashed helicopter with Kevin Dooley inside, mauled to death. Alpha Team was then immediately attacked by a pack of wild dogs, and one of their members, Joseph Frost, was torn to pieces. Alpha Team tried to save Joseph but was shocked to discover their bullets had little effect on the grotesque dogs. Seeing the horrifying scene causes Alpha Team's pilot, Brad Vickers, to take off with their helicopter, leaving Alpha Team stranded in the Arklay Mountains.
Our heroes have no choice but to flee to whatever shelter they can find. They spot an abandoned mansion and immediately rush inside, locking the door behind them. The only members of Alpha Team left on this mission are Chris Redfield, Jill Valentine, Barry Burton, and Albert Wesker. After getting their bearings from being chased by the mutant dogs, Alpha Team decides to split into groups to explore the mansion.
They find what they assume to be the culprit behind the cannibalistic murders feasting on the corpse of Kenneth Sullivan, one of Bravo Team's members. A grotesque, rotting man that felt no pain from gunfire but a bullet to the brain quickly dispatches the monster. However, he wasn't the only one — it turns out this mansion was crawling with undead zombies. As Alpha Team's exploration of the mansion continues, they discover that zombies weren't the only evil residents. There were mutant crows, spiders, snakes, sharks, plants, and even humanoid lizardmen. Not to mention this mansion was also laden with death traps and puzzles to deter intruders.
After evading all of those hurdles, they manage to find Rebecca Chambers, who sadly was the only surviving member of Bravo Team. Alpha Team eventually finds a laboratory hidden underneath the mansion and discovers the truth. All these monsters were the result of the T-Virus and Umbrella's goal was to produce Bio-Organic Weapons (B.O.W. for short) and sell them off to militaries worldwide. However, the Queen Leech posing as Dr. Marcus leaked T-Virus, turned all the research staff into zombies, and released all the locked-up B.O.Ws to cause widespread chaos. They also discover Albert Wesker's true identity as one of Umbrella's top researchers.
Our S.T.A.R.S. confront Albert Wesker, and he coldly confesses that he was working for Umbrella the whole time. He informs them that S.T.A.R.S was brought here to test out the B.O.W.'s combat abilities. Once they were dead, Wesker would gather the combat data and bring it back to Umbrella, but Albert Wesker has other plans. He plans to double-cross Umbrella and sell the data to one of their rival companies because he feels the T-Virus outbreak will lead to Umbrella's financial ruin.
Before he leaves, Albert Wesker activates the mansion's self-destruct protocol to destroy any evidence of the incident. He also unleashes the T002-Tyrant, the culmination of Umbrella's T-Virus research, and orders it to kill our heroes. However, the Tyrant proves somewhat unstable and goes berserk, killing Albert Wesker in the process. After an intense battle, our heroes manage to escape the mansion before it explodes thanks to pilot Brad Vickers coming back to pick them up at the last minute.
The only known survivors of this incident are Jill, Chris, Barry, Brad, and Rebecca. They breathe a sigh of relief, but deep down they know this nightmare is far from over.
Raccoon City's finest police force, S.T.A.R.S have been sent to the Arklay Mountains to investigate a series of murders. The mission quickly turns into a nightmare as the team now struggles to survive in a mansion filled with zombies.
Buy from: Xbox
Resident Evil 2
Two months after the events of Resident Evil 1, Resident Evil 2 kicks off in late 1999. We see a young man named Leon Kennedy is driving towards Raccoon City to attend his first day on the local police force. When he gets there, however, he finds the city overrun with undead zombies. Leon meets one of the survivors amidst the chaos, a young woman named Claire Redfield. Claire tells Leon she came to Raccoon city looking for her brother Chris Redfield because she lost contact with him a couple of months ago. After a disastrous car crash, the pair get separated and agree to meet up at the Raccoon City Police Department.
When they get there, they find the Police Department crawling with zombies and mutated abominations. They managed to find a surviving officer, Marvin Branagh, but he's been bitten by the zombies. He informs our heroes that everyone else has been killed, and they should save themselves. Claire also finds a diary left behind by Chris, which implies that he has left Raccoon City and traveled to Europe. With no reason left to stay, Leon and Claire decide to escape Raccoon City while rescuing any survivors along the way.
It is here where Leon and Claire's paths diverge. After using an emergency escape exit provided by Marvin, Leon meets an FBI agent named Ada Wong. Leon asks Ada if she knows what's going on, but she tells him to get out while he still can. He later encounters Ben Bertolucci, a journalist locked up in prison. He tells Leon that the Umbrella Corporation was responsible for the zombie outbreak, and they bribed the chief of police, Brian Irons, to keep his mouth shut. Leon is skeptical, but before he can ask any more questions, a giant man busts through the walls and kills Ben.
This is the T00-Tyrant (a.k.a. Mr. X), a B.O.W. sent by Umbrella to kill witnesses to the viral outbreak. Mr. X almost kills Leon, but Ada Wong saves at the last minute by ramming Mr. X with a police van. She confirms Ben's story and says she's been tracking down an Umbrella scientist responsible for this disaster, Annette Birkin. Leon demands that he joins her investigation so they can bring down the people who ruined Raccoon City and its people. She reluctantly allows him to join her, and together they begin tracking down Annette and the virus that caused the outbreak: the G-Virus.
Meanwhile, Claire Redfield encounters a little girl named Sherry Birkin looking for her mother. Not long afterward, Sherry gets kidnapped by police chief Irons and takes her to the Raccoon City orphanage. When Claire gets there, she finds Irons killed, with a parasite bursting out of his chest. Thankfully, Sherry is alive, and they make their escape through a secret passage in Irons' office. However, Mr. X arrives and gives chase. Mr. X corners Claire and Sherry in an elevator, but he gets ripped apart by the mutant that infected Irons with the parasite. Sherry says the monster is (or was) her father, before the elevator collapses from the chaos, causing them all to fall into Umbrella's sewer facility.
Claire wakes up to meet Annette Birkin, Sherry's mother, who takes Sherry Birkin to a secure location. Claire goes after Sherry to make she's okay despite Annete's protests. Claire is shocked to discover that Sherry has been infected, and she's beginning to turn. Annette, via an intercom, says there's a way to cure her at the NEST facility. Claire asks for her help, but Annette refuses, as she is busy trying to stop the monster she calls 'William'. So Claire decides to take Sherry to NEST by herself. Coincidentally, that's where Leon and Ada headed to as well.
Both parties arrive at NEST with their objectives — Leon and Ada are tracking down the G-Virus while Claire is looking for a cure for Sherry. Along the way, they discover the cause of the outbreak in Raccoon City. Dr. William Birkin had finished completing the G-Virus and was planning to sell his research to the US military. Umbrella higher-ups find out about William's betrayal and send in their paramilitary unit, the Umbrella Secret Service (U.S.S. for short) to secure the G-Virus. William refused to hand over the virus and was gunned down by U.S.S. agents when he resisted. In a last-ditch effort to stop Umbrella from stealing his life's work, William injects himself with the G-Virus and mutates into the B.O.W. now stalking the facilities. Driven mad by the mutations, William kills the U.S.S. agents and destroys the virus samples they took. Rats ingest the shattered samples and they quickly spread the G-Virus throughout Raccoon City.
When Claire and Leon get what they came for, they run into William Birkin. Annette arrives an in attempt to kill him for good but gets critically injured by William. After beating him, the following scene is different depending on who you play as. In Leon's story, Annette tells Leon that Ada Wong is not an FBI but a spy that's trying to steal the virus and sell it on the black market. Leon can't believe this and confronts Ada Wong about it. Ada immediately admits it and pulls a gun on Leon but can't bring herself to kill him. Annette then shoots Ada, causing her to fall to her doom along with G-Virus sample. Meanwhile, in Claire's story, Claire and Annette manage to cure Sherry of the G-Virus. Annette dies from her injuries sustained in her earlier encounter with William.
When Leon took the G-Virus samples, NEST's self-destruct protocols activate. With no time to spare, Leon, Claire, and Sherry rush off to find an escape route. While taking different elevator shafts, they each encounter an obstacle. Leon fights Mr. X one last time, and Claire fights William Birkin in a new, heavily mutated form. Ada manages to survive her fall thanks to her gadgets and tosses a rocket launcher to Leon (who has no idea she's still alive), saying that they're now even. Leon and Claire defeat the monsters and manage to get on a train, just in time to escape the exploding facility. Their reunion is cut short when the train gets boarded by William Birkin, who has mutated to the point where he's just a giant blob of tentacles, meat, teeth, and eyeballs. Leon and Claire barely manage to cut off the train carriage William was clinging to in time before the explosion caught up to them. After many battles, William Birkin finally dies in the exploding facility.
Leon, Claire, and Sherry come out of the side of the tunnel, surviving the longest night of their lives. Afterward, Leon and Claire decide that they're going to take down Umbrella for what they have done, once and for all.
Resident Evil 2
Young police officer, Leon Kennedy, travels to Raccoon City for his day on the police force. He arrives to find Raccoon City burning and festering with the undead. He bands together with Claire Redfield to escape the zombie hordes and try to uncover the origins of this viral outbreak.
Buy from: Xbox
Resident Evil 3
Resident Evil 3 begins shortly after Resident Evil 1. Chris, Jill, and Barry are making a request to the Raccoon City police chief, Brian Irons to conduct a full-scale investigation of Umbrella, who vehemently denies them. They soon find out that Umbrella's influence reached all corners of Raccoon City and that they can't trust any officials. They were on their own. Chris heads off to Europe to investigate Umbrella's Europe branch, with Barry following behind after relocating his family to Canada. Jill decides to stay behind to see if she can get any dirt on Umbrella in Raccoon City.
Two months later, Jill's investigation has been ground to a halt. Brian Irons disbands S.T.A.R.S., suspends Jill from the police force, and places her under house arrest. Due to the lack of progress of her investigation and Irons' constant surveillance, Jill decides that now is the time to leave Raccoon City and join Chris and Barry in Europe. As she prepares to leave, she is attacked by a new Tyrant creature, codenamed Nemesis.
Umbrella has sent Nemesis to kill all members of S.T.A.R.S for their meddling in Umbrella's affairs. After a tense chase, Jill manages to give Nemesis the slip for now. She meets up with Brad Vickers, and the pair quickly discover that Raccoon City has descended into pure chaos. Zombies are everywhere, and people are dying left and right. They quickly take shelter in a bar, but Brad gets bitten by one of the zombies. Realizing he's doomed, he stays behind to hold off the zombie horde, buying Jill enough time to escape.
While evading the zombies, a rescue helicopter spots Jill, and the pilot tells her to rendevous at the parking garage. When she gets there, Nemesis destroys the chopper, cutting off her escape. With nowhere to run, Jill decides to take out the Tyrant by running him over with a car, to no avail. As Nemesis looms over Jill, a soldier distracts Nemesis and blasts away the Tyrant with a rocket launcher. Nemesis survives but is incapacitated. The soldier, Carlos Oliveira, takes Jill to the subway, where other survivors are gathered.
Carlos explains he is with the Umbrella Biohazard Countermeasure Service (U.B.C.S. for short), and he has been sent to rescue any survivors. When they get to the subway, they meet Carlos C.O., Mikhail Viktor. Mikhail explains that they're trying to fix the train so they can evacuate the survivors, but their platoon has been nearly wiped out, so he asks Jill for help. Jill is apprehensive at first, considering that these guys are working for Umbrella, but she ultimately agrees because she wants to help the survivors, not Umbrella.
During her trek through the city, Jill finds an injured U.B.C.S. soldier, but he's quickly shot dead by another U.B.C.S. soldier, Nikolai Zinoview. Jill gets into a heated argument with Nikolai, but he dismisses her for being a bleeding heart. She gets the subway system back online and heads back to the train station. When she gets back, Nemesis shows up again. She decides to lure Nemesis away to buy the U.C.B.S. soldiers enough time for the train to be fully fixed.
Jill's battles with Nemesis are long and intense. Nemesis tries to burn her alive with a flamethrower and blow her to bits with a rocket launcher. With some quick thinking and teamwork from Carlos, they manage to defeat Nemesis by blowing up a nearby a gas tanker. Once they get back to the train station, Carlos says he has to stay behind because he has orders to find Dr. Nathanial Bard. Bard is a scientist whose vaccine research could save Raccoon City. Jill departs on the train with Mikhail, Nikolai, and the rest of the survivors.
During their ride, Nemesis attacks the trains and kills the survivors. An enraged Jill tries to fight him, but Mikhail holds her, saying they need to retreat. As they do so, Nikolai locks them inside, revealing himself to be a traitor. Nemesis mortally wounds Mikhail, but before he can kill him, Mikhail detonates a C4 charge, hoping to take Nemesis out with him. The explosions derail the train and knock Jill out cold.
Meanwhile, Carlos and fellow U.C.B.S. officer Tyrell search Raccoon City for Dr. Bard. They arrive at the Police Department and contact the doctor by using the officer computers. Dr. Bard says he's trapped at the Spencer Memorial hospital and that Umbrella's been killing off all the Umbrella researchers to cover up the incident. Carlos then gets a call from Jill telling him that Nemesis killed everyone on the train and that Nikolai left them to die. Jill then gets interrupted by Nemesis, who has horrifically mutated due to his injuries. Carlos immediately drops what he's doing and rushes to help Jill.
Jill manages to fight off the animalistic Nemesis, but he manages to impale Jill with a tentacle, infecting her with the T-Virus. Carlos finds Jill unconscious, slowly but surely starting to turn into a zombie. He carries her to the hospital, hoping that Dr. Bard's vaccine can cure her of the T-Virus. When Carlos gets to the hospital, he finds Dr. Bard has been shot in the head, most likely by Nikolai. Carlos finds Dr. Bard's personal computer and discovers a personal log entry from the doctor. Dr. Bard details the location of the vaccine and confesses that Umbrella was indeed responsible for the viral outbreak. Carlos doesn't take this revelation very well. Nonetheless, he gets a sample of the vaccine and gives it to Jill just in the nick of time.
Tyrell meets up with Carlos and brings him some terrible news. The US government has declared that they are launching a missile strike to destroy Raccoon City on October 1, 1998, because the outbreak has become uncontainable. Carlos tells Tyrell to contact the government to hold off the missile strike because they have found the vaccine. Carlos then heads off the Umbrella's underground facility, NEST2, where the rest of the vaccine is located.
Jill wakes up to discover the news about Raccoon City's impending destruction. Tyrell tells her that Carlos has gone off to get the vaccine, but he lost contact with him some time ago. Jill then heads off to NEST2 to help Carlos. Tyrell joins her after contacting the government, he says they're willing to call off the missile strike if they can retrieve the vaccine in a few hours. When they get to NEST2, they are attacked by Nemesis again, who kills Tyrell.
After evading Nemesis, Jill manages to create a sample of the vaccine needed to save Racoon City. Unfortunately, she drops it after a scuffle with Nemesis. Nikolai grabs the vaccine and offers Jill a deal — if she fights Nemesis while Nikolai records the battle, he will give her back the vaccine. Jill has no choice but to do what Nikolai says for now. The battle isn't going well for Jill, but Carlos arrives to save her by drowning Nemesis in a pool of acid.
Jill then pursues Nikolai to retrieve the vaccine but is stopped yet again by Nemesis. Who, at this point, has mutated into a giant amorphous blob of flesh and tentacles. Jill tells Carlos to go after Nikolai while she deals with Nemesis one last time. Thankfully for Jill, the area they're in happens to contain a gigantic experimental railgun weapon. After dismembering Nemesis with the railgun, Jill fires it directly in Nemesis's grotesque face, finally destroying the Tyrant for good.
Jill catches up with Carlo, but he's been knocked out by Nikolai. Nikolai overpowers Jill and destroys the vaccine, dooming Raccoon City. Nikolai reveals he's a mercenary hired to reduce Umbrella to rubble and collect combat data of the B.O.W.s in action. As Nikolai prepares to kill Jill, Carlos wakes up to put Nikolai in a chokehold and tells Jill to shoot him. They manage to incapacitate Nikolai by shooting him in the shoulder. Jill tries to interrogate Nikolai about his motives and who his employer is, but Nikolai responds with cryptic answers and asking for money. Having enough of Nikolai's nonsense, Jill decides to leave him behind to die along with Raccoon City. Nikolai warns Jill that she'll never find out if she leaves him, but Jill says she doesn't mind doing some detective work.
As Carlos and Jill escape in a helicopter, they watch the missile strike reduce Raccoon City to ashes. Jill mourns the loss of her home and contemplates that this horrific tragedy wasn't caused by viruses but by human greed. She vows to dedicate her life to bring down Umbrella and avenge all the good people who died in Raccoon City.
Resident Evil 3
The T-Virus has spread to Raccoon City, turning all of its people into zombies. Jill Valentine prepares to leave her lost city behind, but she will have to contend will Umbrella's latest creation, Nemesis, if she hopes to survive.
Buy from: Xbox
Resident Evil Code: Veronica X
Three months have passed since the destruction of Raccoon City, and Claire Redfield is still searching for her brother, Chris Redfield. Her journey takes her to an Umbrella facility in Paris, but she is immediately discovered by security. They knock out Claire and take her to Rockford Island to interrogate her. Her imprisonment doesn't last long as when she wakes up, she finds the island devastated and crawling with zombies.
Taking this opportunity to escape, Claire leaves her cell and tries to find a way off the island. Along the way, she runs into an inmate named Steve Burnside, and they agree to find an escape route together. Claire tells Steve she's searching for her brother, and Steve remembers overhearing the guards keeping tabs on Chris. Claire finds a nearby computer terminal and emails Leon Kennedy, to try and inform Chris of her whereabouts and that Umbrella is onto him.
As Claire's search continues, she encounters the commanding officer of Rockfort Island, Alfred Ashford, the grandson of one of Umbrella's founders, Edward Ashford. Alfred demands to know why Claire attacked Rockfort Island, but Claire has no idea what he's talking about. Alfred says an air raid strike attacked the island, and the ensuing chaos caused the island's stockpile of T-Virus samples to leak, killing all of the island's staff.
After overcoming numerous traps set by Alfred, Claire and Steve make their way to the Ashford Estate. When they arrive, they are obstructed not just by Alfred, but also by his sister, Alexia Ashford. However, they are shocked to discover that Alexia was actually just Alfred, portraying his sister through some warped obsession. In a moment of psychotic rage, Alfred activates the island's self-destruct sequence to take the pair out. Claire and Steve manage to find an airplane and escape the island before it explodes. However, Alfred activates the plane's auto-pilot by remote and directs it to crash into an Umbrella base in Antarctica.
Claire and Steve manage to survive the crash and begin exploring the base. Alfred makes one last attempt to kill the pair, but Steve shoots Alfred, causing him to fall into a deep chasm. The noise from the battle causes a failed B.O.W., Nosferatu, to awaken and attack Claire and Steve. They defeat the ancient mutant by shooting it in the heart. Claire and Steve find a nearby snowmobile and attempt to escape the base. A dying Alfred crawls to a hidden laboratory and releases the real, mutated, Alexia Ashford from cryogenic stasis. Alexa uses her mutant appendages to capture Claire and Steve to use them for her sick experiments.
Chris Redfield finally arrives at Rockfort Island only to discover it's in ruins. He explores the island hoping that Claire is alive amongst the wreckage, but he finds the last person he ever wanted to see again — Albert Wesker. Not only did Albert Wesker survive getting impaled by the Tyrant in Resident Evil 1, but he somehow also gained superhuman speed and strength. As well as enhanced regenerative healing.
He tells Chris that he's now working for a new company, The Organization, and has been tasked with retrieving Alexa Ashford. After dominating Chris with his newfound abilities, Albert Wesker decides to allow Chris to live. During the one-sided fight, Wesker lets slip that Alexia is in the Antarctica base alongside Claire. Wasting no time, Chris grabs one of the few remaining airplanes and flies off to save his sister.
While exploring the base, Chris discovers notes detailing the Ashford twins' origins. Their father, Alexander Ashford, was conducting experiments to clone their ancestor, Veronica, to bolster their family's reputation within Umbrella. The experiments resulted in two clones of Veronica — Alfred, and Alexia Ashford. When the children discovered they were nothing but a means to an end, they kidnapped their father and experimented on him as an act of revenge. Alexander was transformed into the B.O.W., Nosferatu. Their experiments on their father led to a variant of the T-Virus, which Alexia christened, the T-Veronica Virus. She injected herself with it and put herself into cryogenic stasis for 15 years so that the virus can mutate slowly without degrading her mind.
Chris eventually finds Claire, but they are soon separated again by Alexia. Chris tells Claire to rescue Steve while he deals with Alexia. Claire finds Steve but is shocked to discover that he's been mutated by the T-Veronica Virus and has lost his mind. One of Alexia's tentacles restrains Claire so that the mutated Steve can finish her. However, Steve manages to regain his mind upon hearing Claire's desperate cries for help. He saves Claire but is mortally wounded by Alexia. Steve confesses his love to Claire before passing away.
After fending off a mutated Alexia, Chris activates the base's self-destruct sequence to unlock all doors of the facility. While they are making their escape, they reencounter Alexia, who has mutated into a giant insectoid monster. Chris manages to destroy Alexia for good by using an experimental laser cannon that was nearby. Unfortunately, Albert Wesker abducted Claire while Chris was fighting Alexia. He makes Wesker release Claire by goading him into a fight. Chris tells Claire to prep Chris's harrier jet for take-off while he fights Wesker. Just before she leaves, Wesker taunts Claire by saying that he's taken Steve's body back to his employer for research.
Chris and Wesker's battle comes to a draw when the crumbling base separates the pair of them. Wesker and Chris vow to finish their fight the next time they meet. Chris catches up to Claire, and they both fly away as the Antarctica base explodes.
Resident Evil Code: Veronica X
Claire Redfield continues to search for her missing brother after the destruction of Raccoon City. Her journey takes her to the Umbrella base, Rockfort Island, where it has been overrun with zombies. Now she must escape with the help with the aid of Steve Burnside.
Buy from: Xbox
Resident Evil 4
After many setbacks and investigations, Umbrella was eventually found guilty by the US government for their illegal experiments and causing the viral outbreak in Raccoon City. The compensation charges bankrupted the company, and they were shut down in 2004. Umbrella may be gone, but there were other evil organizations out there, ready to terrorize the world with their biological nightmares.
Years after the destruction of Raccoon City, Leon was recruited by the US government to become a secret service agent owing to his skill and experience. After his training was complete, Leon was assigned his first mission. He must quietly travel to Spain and retrieve Ashley Graham, the United States president's daughter, who has been kidnapped by a cult known as Los Illuminados.
When Leon arrives at a village where Ashley was last sighted, he is attacked by the local villagers. All of whom display unyielding loyalty to Los Illuminados' leader, Osmund Saddler. During his investigation, he meets a man named Luis Cera, who the villagers have tied up. When Leon tries to set Luis free, he gets jumped by one of the cult's enforcers, Bitores Mendez, and is knocked unconscious. Saddler then arrives to inject Leon with a parasite while he sleeps.
Leon and Luis manage to escape their bonds once they wake up and go their separate ways. Before Luiz leaves, he tells Leon that the cult is keeping Ashley locked in their church. After Leon fights his way through the villagers and a couple of giant monsters, he reaches the church where Ashley is being held. Once he frees Ashley, Leon comes face to face with Saddler. Saddler tells Leon that they injected Ashley with a parasite, and once they send her back, the parasite will take control of Ashley and murder the president. Leon and Ashley evade the cult's clutches and begin to make their way to the extraction point.
Unfortunately, the chopper coming to pick them up has been shot down, so Leon and Ashley have to find shelter before another one arrives. After fighting more villagers and defeating Bitorez Mendez, Leon and Ashley find a castle they hope they can hide in until the chopper arrives. Leon and Ashley run then into Luis. He says he knows they have been infected with the parasite. Luis goes off alone to look for a cure while he tells Leon and Ashley to stay alive in the meantime. Leon and Ashley are eventually confronted by one of the Los Illuminados high-ranking members, Ramon Salazar. He has rigged the castle with dozens of traps, and one of them separates Leon and Ashley. Now Leon has to find her again while contending with Salazar's minions.
While exploring the castle, Leon comes across memos left by Luis that reveal that the parasite is named Las Plagas. Leon then gets an unpleasant reunion with Ada Wong. Leon says that he knows that Ada Wong is now working for Albert Wesker and demands to know why she's here. Ada responds with a flashbang and leaves him dazed and confused. Luis then meets up with Leon again with a drug that will stop the parasites infecting Leon and Ashley from growing, along with a sample of Las Plagas. However, Luis gets mortally wounded by Saddler. Saddler retrieves the Las Plagas sample and leaves Luis to die. Luis reveals to Leon that he was a researcher who worked for Saddler, but he defected once he realized how evil his employer was. With his dying breath, Luis gives Leon a drug that will stall the parasite growth and urges him to retrieve the Las Plagas sample before it's too late.
After overcoming dozens of obstacles, Leon catches up with Salazar, but Ashley is long gone. Salazar says Ashley has been taken to an island, miles away. Salazar then mutates into a giant monster and attacks Leon. After defeating Salazar, Leon makes his way to the docks to find a boat that can take him to the island. Ada Wong offers a ride, and Leon begrudgingly agrees since there are no other boats available. Ada then leaves Leon while she does her own work.
The island is a heavily fortified research facility, crawling with armed guards and monsters with regenerative abilities. There Leon encounters Jack Krauser, a soldier that Leon thought died in an accident. Krauser reveals he was the one who kidnapped Ashley and brought her Los Illuminados in the first place. His goal is to revive Umbrella and bring order to the world. Leon's not having of his crazy rhetoric and kills Krauser in a knife fight.
After many setbacks, Leon finally reunites with Ashley. They find a machine capable of eradicating the Las Plagas parasite within a host and use it to cure themselves. While they're finding a way off the island, Leon and Ashley encounter Saddler, and he has taken Ada Wong hostage. Leon tells Ashley to hide and prepares to take down Saddler for good. With some assistance from Ada, Leon blows Saddler to kingdom come with a rocket launcher.
Ada makes off with the Las Plagas sample and gives Leon a key to a jet ski he can use to get Ashley. She tells Leon to get a move on because she's rigged the island to explode in 3 minutes. Leon and Ashley escape the exploding island and proceed to make their way back home. Meanwhile, Ada Wong takes the Las Plagas sample not to Wesker but to the higher-ups of The Organization, leaving Wesker with only scraps.
Resident Evil 4
Leon Kennedy has been sent to rescue the president's daughter, Ashley Graham, from a sinister cult bent on world domination. Keep your aim sharp, and preserve your ammo because the monsters of Los Illuminados don't take kindly to outsiders.
Buy from: Xbox
Resident Evil 5
When Umbrella had dissolved, a new organization had risen to protect the world from bio-terrorism, the Bioterrorism Security Assessment Alliance (B.S.A.A. for short). Chris, Jill, Barry, and Rebecca join the organization to prevent any more tragedies like Raccoon City's destruction from ever happening again.
In 2006, the B.S.A.A. managed to track down Oswell E. Spencer, who went to hiding after Umbrella had fallen apart. The B.S.A.A. sends in Chris and Jill to arrest him and interrogate him on the whereabouts of Albert Wesker. When they get there, they find Albert Wesker has murdered Spencer.
Albert Wesker had been busy over the years. He took over The Organization, made new viruses, and began wiping out any trace of his existence. His latest loose end to tie up was paying a visit to Spencer. However, Spencer was already on death's door due to old age. Spencer decides to reveal to Wesker the true reason for Umbrella's creation before he passes away.
Umbrella wasn't making viruses and monsters for money. The viruses and B.O.W.s were part of many projects designed to create a race of superhumans that Spencer would rule over as a god. Albert Wesker himself was one of those projects, namely the Wesker Project. The company kidnapped several children and injected them with the Progenitor Virus, the first virus Umbrella created. The virus would give the host superhuman abilities but was also almost guaranteed to kill the subject. Albert Wesker survived those experiments and became an employee of the company, but Albert lost all memory of this event. The Progenitor Virus was also responsible for reviving Wesker after he was killed by the Tyrant and granting him his superpowers.
Once he saw no more use for Spencer, Albert Wesker kills him in cold blood. Wesker declares that he will be the god of this world, not Spencer. It was at this time where Chris and Jill barge in, and their fight begins. Even with Jill's back-up, Chris Redfield is still no match for Albert Wesker. As Wesker prepares to finish off Chris, Jill tackles Wesker into a nearby window, both plummeting into the Atlantic Ocean. Their bodies were never found, so they were declared dead, much to Chris' despair.
Three years later, Chris Redfield has been assigned to investigate potential B.O.W. smuggling in Africa. When he arrives at the location where the smuggling is supposed, Kijuju, he meets up with his new partner, Sheva Alomar. They meet one of their contacts, Reynard Fisher, who provides them weapons and intel for their mission. Chris and Sheva are to rendezvous with B.S.A.A.'s Alpha Team to ambush the B.O.W. smuggler, Ricardo Irving. Before they leave, Reynard warns about a doomsday project Irving may be involved in called Uroboros.
On their way to the rendevous point, Chris and Sheva get attacked by the locals who have been infected by a parasite similar to the Las Plagas. After dodging the hostile townsfolk, Chris and Sheva find Alpha Team have been decimated with only one member barely alive, Captain Dechant. He hands Chris a data file containing information on Irving's deal before succumbing to his wounds. Chris and Sheva are then beset upon by a brand new monstrosity, a mass of black worms merging to form a humanoid shape. They manage to burn it to ashes and find a computer to send the data file back B.S.A.A. HQ.
HQ orders Chris and Sheva to head for the mines because intel believes that's where Irving has fled to. Along the way, Chris and Sheva are ambushed by more infected locals, but they're saved by the arrival of the B.S.A.A. Delta Team, led by Captain Josh Stone. Before he leaves to clear the city of more infected, he gives Chris a data file containing info on Irving's dealings. When Chris reads the files, he is shocked to discover an image of Jill Valentine among them.
Chris and Sheva eventually find and corner Irving and attempt to apprehend them. Suddenly, a masked woman crashes through a window and tosses a tear gas grenade to stun Chris and Sheva. The masked woman then carries Irving away. Once they recover their senses, Chris and Sheva read Irving's notes to learn that his next destination is an oil refinery. After dealing with a giant bat B.O.W., a B.S.A.A. agent, Dave Johnson, arrives in a truck to escort Chris and Sheva to Delta Team.
During their trip, Josh contacts Chris and confirms the locals have been infected by the Las Plagas, transformed into monsters called Majini. They lose contact with Delta shortly after. When Chris and Sheva arrive at the rendevous point, they find Delta Team has been wiped out by a giant B.O.W., which crushes Dave Johnson. After Chris and Sheva gun down the monster, they receive orders from HQ to return to base. However, Chris is staying because he believes Jill Valentine is still alive and somewhere amidst this chaos. Sheva thinks this is a bad idea but then grits her teeth and vows to stay with Chris to the end.
Chris then tells Sheva of how Jill supposedly died when they encountered Albert Wesker three years ago. Sheva then tells Chris that her parents were killed in a viral outbreak in Africa caused by Umbrella. So, she joined the B.S.A.A. to make bio-terrorists like Umbrella pay for their crimes against humanity.
As they travel to the oil refinery, they encounter indigenous tribes that have mutated into Majini. In these villages, they spot some tents belonging to TRICELL, a pharmaceutical company that helped fund the B.S.A.A. The tents contain files that implicate TRICELL helped distribute the Las Plagas in Africa. When they get to the oil field, Chris and Sheva find Josh Stone managed to survive the B.O.W. attack. Together they fight off Majini and locate Irving, who is escaping on a boat. With nowhere left to run, Irving infects himself with a Las Plagas sample, given to him by the masked woman, to mutate into a giant sea monster to kill Chris and Sheva.
After sinking Irving's monstrous body, they interrogate Irving about Jill and Uroboros before he dies. Irving curses a woman named Excella and tells Chris he'll find what they're looking for in a nearby cave. Chris and Sheva head for the cave while Josh stays behind to call for backup. While they search the caves, Sheva mentions that Excella is the director of TRICELL's African division, adding further evidence that TRICELL is involved in this mess.
Chris and Sheva find a long-lost, ancient city within the caverns where many Majini lie in wait for them. After fighting them off, they discover a grotto filled with flowers that Umbrella used to create the Progenitor Virus. They have essentially found the origins of Umbrella. Continuing onwards, they find a research facility containing hundreds of people in pods. Chris accesses a computer and finds out Jill was in one of the pods. Excella then appears on-screen and reveals she hacked the B.S.A.A.'s communications to gave the fake orders for the agents to retreat.
Chris and Sheva eventually find Extella, who reveals that Uroboros is a brand new virus designed to help mankind evolve. It merges with the host's DNA, and if it's successful, it will turn the host into a superhuman. Failure to merge will just turn the host into a hideous abomination. After fighting more B.O.W.s, Chris and Sheva corner Excella, but they are attacked by the masked woman again. As they fight, Albert Wesker steps out of the shadows, revealing he was behind the whole scheme all along. He then takes the masked woman's hood off, revealing that it was Jill Valentine. Albert Wesker brainwashed Jill to do his bidding through a device crafted onto her chest.
Wesker leaves Jill to kill Chris and Sheva while he prepares the next phase of his plan. After the most emotionally difficult battle in Chris's life, they barely managed to get the mind control device off of Jill. Jill is too tired from the battle, so she tells Chris to go on ahead stop Wesker from releasing the Uroboros Virus while she recuperates. Chris is concerned about leaving her, but Jill says she'll be fine.
They track down Wesker and Excella to a ship and give chase. They find Excella carrying a couple of briefcases, but she drops one of them as she gets away. Sheva retrieves the contents, which happen to be syringes labeled PG67A/W. Later they reencounter Excella, but she's been infected by the Uroboros. Heartbroken, she reveals she only committed these crimes because she fell in love with Wesker and wanted to rule the world with him. Wesker saw no more use for her, so he infected her with the virus.
Excella transforms into a massive B.O.W., but Chris destroys her by blasting her with an orbital laser. Jill contacts Chris and tells him that the virus which gives Wesker his superhuman abilities is unstable. He needs regular doses of a serum labeled PG67A/W to keep it under control, but it will poison him if Wesker takes too much. Thankfully, Sheva happens to have the serum when Excella dropped it earlier.
They confront Wesker at a stealth bomber that Wesker's planning to use to spread the Uroboros Virus. As the stealth bomber takes off, Wesker goes on a rant about how the world has become overpopulated and plans to use Uroboros to cull humanity and rule the survivors as their god. Chris and Sheva shut Wesker up by injecting him with the serum. Their battle causes the stealth bomber to crash into a nearby volcano.
Now that his plans are completely ruined, Wesker takes in what's left of the Uroboros virus into him. If he can't rule the world, he can least get revenge on Chris. Their final battle is an epic for the ages, filled with fire and brimstone. After what feels like an eternity, Chris and Sheva manage to defeat Wesker, leaving him to burn alive in the volcano. Jill and Josh arrive in a helicopter to pick up Chris and Sheva before the volcano burns them. However, Wesker tries to use what little strength he has left to drag them all to hell with him. Chris and Sheva grab a couple of rocket launchers and blast Wesker to oblivion. Our heroes finally breathe a sigh of relief, content that the last remnants of Umbrella have finally been put to bed for good.
Resident Evil 5
B.S.A.A. agents Chris Redfield and Sheva Alomar have been dispatched to stop a bio-terrorist attack in Africa. Fight the Majinis alone with an AI partner or team up with a friend in co-op to stop the Uroboros project.
Buy from: Xbox
Resident Evil 6
Before we begin, it's important to note that Resident Evil 6's story is told through four campaigns that intersect with each other at various points. To help you understand the events more clearly, we will recap them chronologically rather than recap the campaigns individually.
On December 24, 2012, Chris Redfield led a B.S.A.A. team to quell a B.O.W. attack in Edonia, Eastern Europe. The local rebels are using a new breed of B.O.W. called J'avo to cause widespread chaos throughout the country. Chris gives a motivational speech to his men, and they head off to fight the B.O.W.s.
Meanwhile, we are introduced to Jake Muller, a mercenary working for the Edonian rebels. Jake and the rebels inject themselves with a syringe that is meant to enhance their performance in battle. Jake doesn't feel any effects, but the rebels he's working with mutate into B.O.W.s and attack Jake. Jake kills them without breaking a sweat, annoyed he should've asked for more money.
Jake then is greeted by a young woman and says Jake has antibodies that could save the world. The woman introduces herself as Sherry Birkin, now all grown up and working as a federal agent for US National Security. Sherry explains that the rebels have been tricked into taking a new virus called the C-Virus. This virus is so deadly it could endanger the entire globe if they don't get the antibodies in Jake's blood to stop it. Jake agrees to donate his blood, but only if he is paid 50 million dollars in compensation.
As they leave, they encounter a giant B.O.W. named Ustanak. A monster that resembles Nemesis and is equipped with a giant mechanical claw. As they flee the hulking beast, Sherry mentions that this creature was dispatched by a bio-terrorist group called Neo Umbrella, who also wants Jake's blood for their bio-weapons research. Once they lose Ustanak, they eventually come across Chris Redfield and his team dealing with the J'avo. Chris recognizes Sherry because Claire told him about her and vice versa. One of Chris' men, Piers Nivans, spots Jake Muller and points that he's working for the rebels they're currently fighting. Sherry defends Jake, saying he's under the protection of the US government. Chris notices something familiar about Jake, but before he thinks about it more, another giant J'avo attacks them.
After they defeat the B.O.W., Chris offers some choppers to escort Sherry and Jake to safety. Piers is upset that they're letting a heartless merc like Jake go, but Chris tells him to focus on the mission. Chris's team then runs into Ada Wong, who has been held hostage by the rebels. She explains that Neo-Umbrella was responsible for creating the C-Virus and tricked the Edonian rebels into using it. After escorting Ada out of the rebel stronghold, she lures the B.S.A.A. soldiers into a trap. She bids them farewell with a needle-grenade that infects all of Chris's men with the C-Virus. Chris is horrified at seeing his squad turned into monsters and is knocked out by one of them. Piers managed to avoid the needle grenade and drags Chris away before the B.O.W.s could kill him.
Meanwhile, the Ustanak catches up to Jake and Sherry and attempts to kill them both. Their fight causes the helicopter they were in to crash land into a snowy mountain range. Jake wakes up to find Sherry impaled by some of the wreckage. Jake pulls it out of her, and Sherry begins to heal her wounds instantly. It turns out the G-Virus within Sherry wasn't cured after all, merely mitigated. Thankfully, the G-Virus only grants Sherry regenerative healing abilities instead of horrible mutations like her father, William Birkin.
Ustanak and more J'avo then assault Jake and Sherry. Ustanak knocks Sherry unconscious and restrains Jake at the behest of Ada Wong, now working for Neo-Umbrella. Ada looks at Jake and reveals to him why his blood is so special — Jake Muller is the long-lost son of Albert Wesker. Ustanak knocks out a baffled Jake, and the J'avo take both him and Sherry away.
Six months later, on June 27, 2013, we see Ada Wong infiltrate a submarine. She is here because some time ago the US National Security advisor, Derek C. Simmons, contacted her, saying this submarine held information that was of great interest to her. Ada finds a mission briefing from Simmons addressed to her. It states she needs to capture Jake Muller and prevent the vaccine of the C-Virus from being made. Ada is confused, since these orders were dated six months ago, and she never received such orders before. She thinks either Simmons is playing mind games with her or somebody is impersonating her, taking orders on Ada's behalf.
Ada gets discovered by the submarine's security, who begin shooting at her. The ensuing battle ruptures the submarine's hull and begins to flood the ship. As Ada is escaping the sinking sub, she gets a call from Simmons saying that tomorrow the United States, China, and various major cities will come under bio-terrorist attacks. All of which will be conducted by Neo-Umbrella's "Ada Wong" doppelganger. Annoyed that some Umbrella wannabe is trying to use her as a scapegoat, she escapes the sub and prepares to track her impostor.
A few days later, on June 29, 2013, we find Chris drinking his woes away in a run-down bar in Eastern Europe. The trauma of seeing his men turn into monsters caused Chris to suffer immensely, who resolved to desert the B.S.C.A. Piers manages to locate Chris and helps Chris regain recollection of the event. Determined to avenge his fallen comrades, Chris returns to active duty.
Meanwhile, the president of the USA, Adam Benford, prepares to hold a speech at the Ivy University in Tall Oaks. He plans to reveal the government's involvement in the Raccoon City incident, particularly the part where they partly funded Umbrella's research. He hopes that by telling the truth, this will help the world unite against the war on bio-terrorists. Leon Kennedy is concerned about the backlash that may come from this, but he supports the president's decision.
Unfortunately, a bio-terrorist attack occurs at the university. Nearly everyone at the campus is turned into zombies, including the president. With a heavy heart, Leon Kennedy puts his friend Adam Benford out of his misery. Leon's partner, a secret service agent, named Helena Harper, starts blaming herself for this nightmare. Leon asks why it's her fault, but Helena says she'll explain once they reach Tall Oaks Cathedral.
They are horrified to see the city of Tall Oaks overrun with zombies and monsters as they escape the campus. Just like Raccoon City was many years ago. On their way to the Cathedral, Leon's operator, Ingrid Hunnigan, informs that Neo-Umbrella has claimed responsibility for the attack on Tall Oaks. She urges Leon to get to the cathedral and find out what's going on because Derek Simmons is getting anxious for info.
When they get to the cathedral, Helena takes Leon to a laboratory hidden underneath the building. They search the lab and find a VHS that displays disturbing footage of a woman resembling Ada Wong hatching out of a cocoon. Helena says that isn't what she wanted to show Leon, and what they were looking for lies deeper beneath the cathedral. Leon and Helena find a hidden passage that leads to underground catacombs filled with C-Virus monsters.
They eventually come across what Helena was looking for, her sister Deborah Harper. They try to escort Deborah to safety but they don't get far because she begins to mutate. Sadly though, Deborah has been infected with the C-Virus and attacks them both. The real Ada Wong comes in to help the pair, and together they put down Helena's sister. While Helena grieves for her sister, Leon demands Ada to them what's going on. Ada, as per usual, gives only cryptic answers and leaves to pursue her own goals.
Heartbroken over her sister's death, Helena reveals to Leon that Derek Simmons was behind the attack on Tall Oaks. Simmons kidnapped Deborah and threatened to kill her if Helena didn't help him assassinate the president. Simmons tasked Helena to distracting the president's security while Simmons released a B.O.W. that spread an airborne version of C-Virus amongst the campus, infecting everybody on site.
Leon attempts to contact Hunnigan, but he gets called by Simmons instead. Simmons denies he was responsible for the attack and puts the blame squarely on Helena and Leon. Framing them for the assassination of Adam Benford.
Elsewhere, Ada Wong examines the videotape Leon found. She gets contacted by Simmons, but Ada calls him out, saying he isn't Simmons — but the fake Ada Wong. She's figured out that this fake Ada is the one leading Neo-Umbrella because the real Simmons would never be so cocky to reveal his plans. Especially since any info getting out would endanger Simmons' position and expose his secret organization, The Family. Ada also says the fake Ada wants nothing more than to destroy the system that Simmons' organization had created by causing as much chaos as possible. Before she blows up the lab underneath the cathedral, Ada contacts the real Simmons to let him know that the fake Ada is trying to destroy the world.
After making it out of the catacombs, Leon and Helena see Tall Oaks City destroyed by a missile strike in the distance. Hunnigan contacts Leon and tells him that Simmons has departed for China in a hurry. Knowing that Simmons has framed them, Leon tells Hunningan to fake his and Helena's deaths so they can pursue Simmons without having the government on their tail.
We cut back to Chris Redfield, who has returned to the B.S.A.A to deal with a bio-terrorist attack in China. Neo-Umbrella has kidnapped UN officials and unleashed J'avos into the streets of Lanshiang. Chris struggles against the J'avos, while having horrific flashbacks of his comrades dying in Edonia. Nonetheless, Chris soldiers on.