When Microsoft first debuted Windows 10 S in May, it was clearly targeted at the education market. A large reason for that is due to the fact that it's more secure without the ability to run apps from outside of the Windows Store. That can have its perks in other scenarios as well, particularly when combined with low-cost devices for the enterprise.
At its Ignite 2017 event in Orlando today, Microsoft has announced that new commercial Windows 10 S devices are coming from HP, Lenovo, and Fujitsu. Starting at $275, pricing firmly falls into the low-cost territory, which, combined with simplified management and self-service deployment, Microsoft is hoping will provide an overall reduced cost for businesses.
The devices will also be offered alongside a new Microsoft 365 F1 subscription bundle, which is tailored for firstline workers. The bundle combines Office 365 F1, Windows 10, and Enterprise Mobile and Security and more.
Aside from the students and educators, commercial users seem like a natural fit for Windows 10 S. The Windows Store-bound OS offers a more secure environment and will be available with relatively low-cost hardware. For organizations that must leverage legacy Win32 apps, Windows 10 S is obviously a no-go. However, the arrival of full Office apps on the Windows Store likely alleviates at least one major pressure point for many users.
As for when to expect the devices to arrive, Microsoft doesn't have any firm dates available, but it does say to expect them "later this year."

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