Always great deals
Large online retails like Amazon and Newegg deal a lot in volume, more so than more localized, niche retailers. You won't always find the best deals here, but you can say with a high degree of accuracy there will always be some kind of a great deal on some of the products you're interested in.
Amazon in particular with Prime can make a difference with free shipping and occasional member exclusive deals and pricing.
There's also the possibility to pick up certified refurbished hardware. These are always cheaper than retail price and come with the same protection you'd get buying anything else from a major retailer.
Lots of choice from different card makers
These large online retailers are also some of the best places to compare prices and products across a wide range of manufacturers. The GTX 1080 Ti attracts a number of manufacturer variants with differing designs, custom coolers, factory overclocks, and more to differentiate from the rest.
At both of these stores, you'll find the best graphics cards from all the leading manufacturers, which makes it easier to find not only the right card for you, but also score the best price.
Online tools to help you find deals
If you're shopping for graphics cards like the GTX 1080 Ti there are a couple of awesome online tools that can help you find deals and availability.
For Amazon, CamelCamelCamel is the best tool around, allowing you to compare and track pricing with custom alerts to help you get what you want at the best possible price.
For Newegg and other, smaller retailers, PCPartPicker is a superb resource that tracks daily and weekly deals and price changes on graphics cards.
One other important thing that should be pointed out about both Amazon and Newegg is that they support international customers. Either with local stores or international shipping, you're not isolated just for living outside of the U.S.
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