Best Overall: Logitech MX Master 2S
Available in three different color combinations and equipped with seven buttons, the ergonomic MX Master 2S from Logitech (about $90) is sure to please just about anyone. The rechargeable battery inside should get you about 70 hours of life, and DPI is set at 4,000 for smooth tracking. The overall design is meant to keep your hand in a comfortable position, and grip in the right spots only helps your wrist from cramping up. Connect with Bluetooth or a 2.4GHz dongle, and connect to multiple devices thanks to Logitech Flow.
Bottom line: The best ergonomic mouse out there right now is the Logitech MX Master 2S.
One more thing: Our review has much more information about this awesome ergonomic mouse.
Why the Logitech MX Master 2S is the best ergonomic mouse
Thanks to the smart design, there's really not a single right way to hold the MX Master 2S as long as you're holding it with your right hand. There's a bit of grip to reduce strain on your hand and wrist, and the contoured lines make it sort of sink into your palm.
Choose from Bluetooth or a 2.4GHz dongle to connect (some people find Bluetooth too spotty), and get up to about 70 hours of life from the rechargeable battery. The mouse can also recognize up to three devices at once, and a quick-switch button makes it easy to move back and forth when using more than one PC.
There are seven buttons on this mouse, plus dual scroll wheels — one near your thumb and one in the usual spot — for maximum productivity. If you don't mind a bulkier mouse that's happy to live in your home or office, this is certainly a great ergonomic option.
Best Surface: Microsoft Surface Precision
If you like the idea of the MX Master 2S but would rather have something that matches your Surface device, definitely check out the Surface Precision (about $80). It can also be used with up to three PCs, it connects with Bluetooth, and the rechargeable battery can last up to three months. The ergonomic design is easy on the wrist and hand, and while it doesn't have quite as many bells and whistles as our top pick, the six buttons give you options when it comes to customization.
Bottom line: For an outstanding ergonomic mouse with Surface branding, be sure to check out the Surface Precision.
One more thing: Our review has more information about this comfortable mouse.
Best Trackball: Logitech MX ERGO
Logitech's MX lineup continues with the ERGO (about $90), an outstanding trackball mouse for anyone who'd rather not keep their wrist in constant movement. The ERGO is shaped much like the MX Master 2S, though here you have a smooth ball under your thumb and a hinge that allows you to change the angle from 0 to 20 degrees. You're still getting outstanding life from the rechargeable battery, and there are still plenty of extra buttons you can customize. Connect with Bluetooth or the included dongle.
Bottom line: Love a trackball? Have a look at the Logitech MX ERGO.
One more thing: Interested but not 100 percent sure? Check out our review for more information.
Best Gaming: Razer DeathAdder Elite
At this point, Razer is pretty much synonymous with the PC gaming world, and for good reason. Gamers spend most of their time with a mouse in hand, so something ergonomic will save much pain and cramping. The DeathAdder Elite (about $60) isn't new, but it's certainly one of the most popular gaming mice on the market. Thanks to the smart design it sort of disappears into the palm of your hand, and with DPI up to 16,000, you're getting one smooth ride. The mechanical mouse switches are durable and precise, and a few extra buttons allow for a bit of customization.
Bottom line: Love to game? The Razer DeathAdder Elite can save you from a sore wrist.
One more thing: Have a look at our roundup of the best gaming mice for way more options.
Best Vertical: Evoluent VerticalMouse C
If you're already experiencing pain in your fingers, wrist, or forearm, you might want to look into vertical mice, like the Vertical C from Evoluent (about $90). By turning your hand sideways to grip this odd-looking device, you take some pressure off those sore tendons. Best part? You don't really lose any functionality thanks to the smart design; there's still a scroll wheel and five buttons, with two located on the inside next to the grooved thumb rest.
Bottom line: Want to try something different? Check out this vertical mouse from Evoluent.
One more thing: This mouse if made for right-handers, but there is a left-handed VerticalMouse 4 That has a similar design.
Conclusion
There are plenty of ergonomic mice on the market, including the options we have selected here, but the best overall is still the Logitech MX Master 2S.
Best Overall: Logitech MX Master 2S
Available in three different color combinations and equipped with seven buttons, the ergonomic MX Master 2S from Logitech (about $90) is sure to please just about anyone. The rechargeable battery inside should get you about 70 hours of life, and DPI is set at 4,000 for smooth tracking. The overall design is meant to keep your hand in a comfortable position, and grip in the right spots only helps your wrist from cramping up. Connect with Bluetooth or a 2.4GHz dongle, and connect to multiple devices thanks to Logitech Flow.
Bottom line: The best ergonomic mouse out there right now is the Logitech MX Master 2S.
One more thing: Our review has much more information about this awesome ergonomic mouse.